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Nolvadex as such has no direct anabolic or androgenic effects. All its effects are secondary to the blockage of estrogen receptors. Nolvadex is known to block estrogen receptors in the body. When it blocks the estrogen receptors on the hypothalamus, the brain senses that the body is lacking in this sex hormone. This results in a surge of the Gonadotropins (LH and FSH) which increases the synthesis of the sex hormones. The drug has been shown to increase the synthesis of testosterone.
The surge in testosterone then accounts for the anabolic and androgenic effects of Nolvadex.
Most bodybuilders take Nolvadex after coming off an anabolic steroid. Since most anabolic steroids suppress the testosterone production, Nolvadex can be added during the washout cycle. While some bodybuilders prefer Nolvadex, others prefer Arimidex. The effects of both drugs are similar. Since Nolvadex also blocks the estrogen activity, most bodybuilders add it to their regimen to prevent the gynecomastia and water retention.
There is minimal weight gain with Nolvadex alone. In order to maintain the weight increase induced by other anabolic steroids, Nolvadex is preferred. Used during the washout cycle, the drug can maintain the weight gain and also allows the testes to recover.
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