glutamate dehydrogenase

Glutamate Dehydrogenase: Hero in Metabolic Regulation

09 Feb 2025 By Jax 24/7 Steroids

Glutamate dehydrogenase (GDH) is a crucial enzyme integral to cellular metabolism. It facilitates the conversion of glutamate to α-ketoglutarate and ammonia, impacting nitrogen and carbon metabolism. Located in the mitochondrial matrix, GDH’s activity is tightly regulated by metabolites, aligning with cellular energy needs. Its proper function is vital for amino acid catabolism and maintaining ammonia homeostasis. Medical research highlights GDH’s role in metabolic disorders, including implications in hyperinsulinism-hyperammonemia syndrome.

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