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Semaglutide, primarily used for managing type 2 diabetes and aiding weight loss, presents varying costs depending on insurance coverage. Comprehensive plans covering brand-name drugs can lower out-of-pocket expenses, but coverage specifics differ. Some plans may categorize semaglutide as costly, require alternatives first, or necessitate prior authorization. Medicare patients, especially in the “donut hole,” might face higher costs. Savings programs and coupons from pharmaceutical companies can help alleviate expenses, requiring careful review of benefits and assistance options to reduce financial burdens.