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Bremelanotide is a synthetic peptide originally developed to address sexual dysfunction in premenopausal women. Known as Vyleesi, it activates melanocortin receptors to increase sexual desire. Although it gained interest in fitness circles, its FDA approval is limited to treating hypoactive sexual desire disorder (HSDD). Off-label use in fitness remains unsupported by science, with side effects like nausea and increased blood pressure. Sustainable fitness results are best achieved with proven supplements and rigorous training, rather than using medications outside their intended purpose.